How long does it take for energy supplements to work?

B12 sublingual can show effects within 3–5 days if deficiency is the cause. CoQ10 typically requires 4–8 weeks of consistent use before tissue levels are sufficient. Ashwagandha needs 4–8 weeks for full cortisol and stress-response benefits. L-theanine works within 30–60 minutes when taken with caffeine.

Can you take all the energy supplements together?

Yes, the core four (B12, CoQ10, Ashwagandha, L-Theanine) work through complementary pathways and are safe to stack together. B12 should be taken in the morning; CoQ10 with a fat-containing meal; Ashwagandha morning or evening; L-Theanine with your morning caffeine or in the evening. These four don't have significant interactions with each other.

Which energy supplement should I start with first?

Start with Vitamin B12 if you're not sure. Sublingual methylcobalamin at 500–1,000 mcg daily is one of the safest, most evidence-backed supplements available — and B12 deficiency is extremely common. After 2 weeks of consistent use, assess how you feel before adding CoQ10 or Ashwagandha.

Best Supplements for Energy and Focus in 2026

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